BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid, 2,2μ-(Ethylenedioxy)dianiline-N,N,Nμ,Nμ-tetraacetic acid

Name	1,2-Bis(2-aminophenoxy)-ethane-N,N,N'N'-tetraacetic acid
Synonyms	BAPTA ETHYLENEDIOXYBIS(O-PHENYLENENITRILO)TETRAACETIC ACID 1,2-Bis(2-aminophenoxy)-ethane-N,N,N'N'-tetraacetic acid 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid 1,2-BIS-(O-AMINOPHENOXY)-ETHANE-N,N,N',N'-TETRAACETIC ACID BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid 2,2',2'',2'''-[Ethylenebisoxybis(2,1-phenylenenitrilo)]tetrakisacetic acid 2,2',2'',2'''-[ethane-1,2-diylbis(oxybenzene-2,1-diylnitrilo)]tetraacetate 2,2',2'',2'''-[ethane-1,2-diylbis(oxybenzene-2,1-diylnitrilo)]tetraacetic acid BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid, 2,2μ-(Ethylenedioxy)dianiline-N,N,Nμ,Nμ-tetraacetic acid
CAS	85233-19-8
InChI	InChI=1/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)/p-4
InChIKey	FTEDXVNDVHYDQW-UHFFFAOYSA-N

Molecular Formula	C22H24N2O10
Molar Mass	476.43
Density	1.4482 (rough estimate)
Melting Point	177-179 °C
Boling Point	575.89°C (rough estimate)
Flash Point	417.4°C
Water Solubility	Soluble in water and sodium bicarbonate.
Solubility	Soluble in dimethyl sulfoxide
Vapor Presure	1.03E-24mmHg at 25°C
Appearance	White solid
Color	White to off-white
Maximum wavelength(λmax)	['209 nm, 254 nm, 203 nm, 274 nm']
Merck	14,957
BRN	5192406
pKa	1.40±0.10(Predicted)
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Refractive Index	1.6500 (estimate)
MDL	MFCD00036255
Use	Highly selective calcium chelating reagent. Suitable for spectrophotometric monitoring of Ca2 + levels

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
RTECS	MC0423000
HS Code	29225090

Biological applications
biological activity	BAPTA is a non-permeable, selective calcium ion chelator, the affinity for Ca2 is 105-fold higher than for Mg2. BAPTA is a valuable tool for studying the role of calcium in cell signaling.
Target	Ca 2 chelator
Use	calcium selective chelator.(logKCa = 6.97,logKMg = 1.77), the basic chelating unit is similar to EDTA, and only two fatty nitrogen are replaced by aromatic nitrogen. Therefore, BAPTA will not be protonated at physiological pH. pKa3 was 5.47 and pKa4 was 6.36. This shows that deprotonation is not included in the Ca chelation step. The chelation rate is higher than that of EGTA because it is not interfered by protons. BAPTA-AM is a BAPTA acetyl methyl ester derivative, which is easily loaded into cells by the AM method. BAPTA-AM is useful for intracellular calcium monitoring

Last Update：2024-04-10 22:29:15

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BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid, 2,2μ-(Ethylenedioxy)dianiline-N,N,Nμ,Nμ-tetraacetic acid Request for Quotation